Severe Vitamin D Deficiency May be an Additional Cofactor for the Occurrence of Alcoholic Steatohepatitis.
| Autor: | Anty, Rodolphe, Canivet, Clémence M., Patouraux, Stéphanie, Ferrari‐Panaia, Patricia, Saint‐Paul, Marie Christine, Huet, Pierre‐Michel, Lebeaupin, Cynthia, Iannelli, Antonio, Gual, Philippe, Tran, Albert |
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| Předmět: |
COMPLICATIONS of alcoholism
FIBROSIS BIOLOGICAL assay BIOPSY CHI-squared test CONFIDENCE intervals FATTY liver RESEARCH funding T-test (Statistics) VITAMIN D VITAMIN D deficiency LOGISTIC regression analysis CROSS-sectional method DESCRIPTIVE statistics ODDS ratio MANN Whitney U Test DISEASE complications DIAGNOSIS |
| Zdroj: | Alcoholism: Clinical & Experimental Research; Jun2015, Vol. 39 Issue 6, p1027-1033, 7p |
| Abstrakt: | Background Among its pleiotropic effects, vitamin D may protect the liver from fibrosis and/or inflammation. However, the impact of vitamin D on liver pathology in hepatitis C remains unclear, and very few studies including alcoholic patients with liver pathologies have been performed. Here we compared the levels of 25- OH vitamin D in the blood of alcoholic patients with the occurrence of alcoholic steatohepatitis (ASH) or bridging fibrosis. Methods One hundred and one alcoholic patients were included. All the patients received a liver biopsy, and the levels of 25- OH vitamin D were evaluated with the Liaison 25-OH vitamin D assay. Logistic regression analyses were performed to obtain predictive factors of liver histology. Results Among alcoholic patients, 40.6% presented ASH and 39.6% presented bridging fibrosis. A severe deficiency in 25-OH vitamin D (<10 ng/ml) was seen in 60.4% of patients. This deficiency was frequent in patients with ASH (85.4%) and in those with bridging fibrosis (80%) but was independently associated only with ASH (odds ratio = 8.46 [95% confidence interval 2.05 to 34.89], p = 0.003). Conclusions In alcoholic patients, a severe deficiency in 25- OH vitamin D was independently associated with the occurrence of ASH. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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