| Autor: |
Cibella, Fabio, Cuttitta, Giuseppina, Bellia, Vincenzo, Bucchieri, Salvatore, D'Anna, Silvestre, Guerrera, Daniela, Bonsignore, Giovanni |
| Předmět: |
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| Zdroj: |
CHEST; Dec2002, Vol. 122 Issue 6, p1944, 5p |
| Abstrakt: |
Study objective: We evaluated the longitudinal changes in lung function and the factors associated with FEV[sub 1] changes over time in a sample of asthmatic subjects. Setting: FEV[sub 1] measures were recorded every 3 months over a 5-year follow-up period. To compare all subjects independently of body size, FEV[sub 1] values were normalized for the subject's height at the third power. We evaluated the possible effect of age, baseline FEV[sub 1], disease duration, and FEV[sub 1] variability on the rate of change of FEV[sub 1]. Patients: We studied 142 subjects with asthma diagnosed on the basis of validated clinical and functional criteria. Results: FEV[sub 1] showed a linear decay with aging in each subject. For a subject 1.65 m in height, the median overall FEV[sub 1] decay was 40.9 mL/yr. FEV[sub 1] decay slopes were significantly influenced by age and sex, being steeper in younger male subjects. A significant interaction was found between age and baseline FEV[sub 1]: the FEV[sub 1] decay was significantly higher among younger asthmatics with a poorer baseline functional condition. A longer disease duration was associated with a lower FEV[sub 1] slope. FEV[sub 1] variability was strongly associated with an increased rate of FEV[sub 1] decline. Conclusions: FEV[sub 1] decline in patients with bronchial asthma is significantly influenced by baseline FEV[sub 1], disease duration, and FEV[sub 1] variability. Moreover, the rate of FEV[sub 1] decline seems to increase in younger subjects only when the baseline function is poorer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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