| Autor: |
Rahman, Faiz-Ur, Ali, Amjad, Guo, Rong, Wang, Wei-Kun, Wang, Hui, Li, Zhan-Ting, Lin, Yuejian, Zhang, Dan-Wei |
| Předmět: |
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| Zdroj: |
Dalton Transactions: An International Journal of Inorganic Chemistry; 6/7/2015, Vol. 44 Issue 21, p9872-9880, 9p |
| Abstrakt: |
A series of trans-Pt(ii)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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