| Autor: |
Irvine, Mark W., Guangyu Fang, Eaves, Richard, Mayo-Martin, Maria B., Burnell, Erica S., Costa, Blaise M., Culley, Georgia R., Volianskis, Arturas, Collingridge, Graham L., Monaghanb, Daniel T., Jane, David E. |
| Předmět: |
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| Zdroj: |
Synthesis; 2015, Vol. 47 Issue 11, p1593-1610, 18p |
| Abstrakt: |
9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-D-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter L-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain, and in neurodegenerative disorders such as Alzheimer's disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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