| Autor: |
Ling Zhong, Joshua Brown, Audra Kramer, Kaleka, Kanwardeep, Petersen, Amber, Krueger, Jamie N., Florence, Matthew, Muelb, Matthew J., Battle, Michelle, Murphy, Geoffrey G., Olsen, Christopher M., Gerge, Nashaat Z. |
| Předmět: |
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| Zdroj: |
Journal of Neuroscience; 5/13/2015, Vol. 35 Issue 19, p7503-7508, 6p |
| Abstrakt: |
Increasing plasticity in neurons of the prefrontal cortex (PFC) has been proposed as a possible therapeutic tool to enhance extinction, a process that is impaired in post-traumatic stress disorder, schizophrenia, and addiction. To test this hypothesis, we generated transgenic mice that overexpress neurogranin (a calmodulin-binding protein that facilitates long-term potentiation) in the PFC. Neurogranin overexpression in the PFC enhanced long-term potentiation and increased the rates of extinction learning of both fear conditioning and sucrose self-administration. Our results indicate that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. Thus, neurogranin can provide a molecular link between enhanced plasticity and enhanced extinction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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