| Autor: |
Hingrajia, Nirav M., Desai, Hemina, Goswami, Hansa M., Gosai, R. N., Malukani, Pankaj |
| Předmět: |
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| Zdroj: |
NHL Journal of Medical Sciences; Jan2015, Vol. 4 Issue 1, p70-74, 5p |
| Abstrakt: |
Background Transrectal ultrasound (TRUS)-guided needle biopsies of prostate are considered as gold standard for the diagnosis of the prostatic cancer. Objectives To determine the spectrum of pathological lesions in TRUS-guided needle biopsies of prostate in men with increased serum prostatic specific antigen (PSA) levels with or without symptoms of prostatism and also histopathological characteristics of carcinoma. Patients and methods A prospective study carried out at the Department of Pathology, B.J. Medical College, Ahmedabad from May 2013 to July 2013. 200 men underwent TRUSguided prostate biopsies for suspected prostate cancer. Raised serum PSA levels were arbitrarily divided into mild (= 4 to 10ng/ml), moderate (= 10.1 to 20 ng/ml) and marked elevations (20.1 ng/ml & more). In most cases, eight cores were taken. Each core were processed with routine paraffin method and stained with standard hematoxylin & eosin stain and for reporting of malignant cases Gleason's grade and score is used. Results The mean age of patients was 66±9 years (range: 57-75 years). The mean serum PSA was 13.6±11.2 ng/ml. Mean number of cores obtained per case was 7±2 (range: 5-9). In present study, 150 (75%) cases showed benign lesions and 50 (25%) were malignant. Benign lesions consisted of benign prostatic hyperplasia. 70 of benign cases (46.6%) showed significant inflammatory changes. Among malignant lesions, most were of moderate to high Gleason grades and scores. Mild serum PSA rise was seen in 96 (48%) patients; among these, 91 (94.7%) cases showed benign lesions and 5(5.2%), malignant. Moderate serum PSA rise was seen in 51 (25.5%) cases; among these 43 (84.4%) were benign and 8(15.6%) malignant. 53 (26.5%) patients had serum PSA = 20.1 ng/ml. Among these, 37 (70%) had adenocarcinoma, 16 (30%) hyperplasia, one of the later with nonspecific prostatitis. Conclusions The detection rate of prostate cancer is similar to that reported previously from around the world and rises with an increase in serum PSA level and correlate very well. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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