Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.

Autor:	Mazouni, Chafika, Fina, Frédéric, Romain, Sylvie, Bonnier, Pascal, Ouafik, L'houcine, Martin, Pierre-Marie
Předmět:	BREAST cancer treatment CANCER relapse ADJUVANT treatment of cancer CANCER hormone therapy PROGESTERONE receptors NOMOGRAPHY (Mathematics)
Zdroj:	Journal of Cancer Research & Clinical Oncology; Jun2015, Vol. 141 Issue 6, p1083-1088, 6p
Abstrakt:	Purpose: To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC). Methods: We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed. Results: A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status ( p < 0.001), nodal status ( p = 0.008) and cathepsin-D ( p < 0.001) were retained to construct the nomogram (C-index 0.734). Conclusions: The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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