| Abstrakt: |
Objective: Further study to the clinical study on the treatment of recurrent Candida vulvovaginitis and intestinal homologous Candida infection. Methods: Collect and identify vulva vaginal secretion and anal swab strains of recurrent Candida vulvovaginitis patients in June 2009 to March 2013 in obstetrics and gynecology clinic, for double-positive patients, determine the homology of Candida mycoderma bacteria got by separating secretion and anal swab strains by the method of PCR, divide the patients into two types of homologous patients and non homologous patients. Two types were respectively assigned to four groups randomly. Group A (homologous systemic treatment group) and group B (non homologous systemic treatment group) were treated with oral fiuconazole, group C (homologous local treatment group) and group D (non homologous local treatment group) were treated with external using Miconazole Nitrate Suppositories at least 6 months. And the patients of group A and B should be consolidation therapy at least 6 months. Follow up 1 year after four groups patients recovered (Curative effect evaluation in the result of Candida microscopic examination and culture were negative), to observe the relapse of four groups patients. Results:Total 160 patients were enrolled in RVVC patients, covered 110 cases of RVVC homology patients and 50 cases of patients with non homologous. Follow up the treatment effect, group A showed that the recurrence rate of the patients with a minimum of 10.7%, recurrence rate of C, D are high with 70.4% and 69.2%. In the fact of first time to relapse and recurrence degree, group A is better than the other three groups, while group C and D are relatively worse. In addition, homology test of double positive and part of double positive patients with recurrent showed that the effect of systemic treatment is better than local treatment. Conclusions: Further confirmed that strains transition between recurrent Candida vulvovaginitis and intestinal homologous Candida infection probably has the close relationship with the reason why part of RVVC patients last long illness. [ABSTRACT FROM AUTHOR] |
