| Autor: |
Patel, Gayatri C., Patel, Shruti V., Patel, Ankita U., Shah, Dinesh R. |
| Předmět: |
|
| Zdroj: |
Pharma Science Monitor; Jan-Mar2015, Vol. 6 Issue 1, p51-61, 11p |
| Abstrakt: |
Ondansetron Hydrochloride is a potent antiemetic drug indicated for the treatment and/or prophylaxis of postoperative or chemotherapy- or radiotherapy-induced emesis. It is extremely bitter in taste. The purpose of this research was to mask the bitter taste of Ondansetron Hydrochloride with carbopol by neutralization method. The effect of variables like type of alkali, concentration of alkali, grades of carbopol and concentration of carbopol on bitterness level was studied. Results showed that neutralization of drug with equimolar sodium hydroxide and subsequent complexation with 0.6% carbopol 971G gave effective taste masking. The drug polymer complex was used to formulate orodispersible tablets by direct compression method using three different superdisintegrants like croscarmellose sodium, crospovidone and Kyron T- 314. The prepared tablets were evaluated for the parameters like general appearance, thickness, hardness, weight variation, friability, wetting time, water absorption ratio, in vitro and in vivo disintegration time. The disintegration tests showed rapid disintegration within 25-42 seconds. In vitro dissolution studies showed 100% drug release in 10 minutes. The formulations were subjected to stability testing for three months at 25°C/60%RH and 40°C/75%RH. Results revealed no appreciable change in any of the formulations. It is concluded that the method attempted here for formulation of orodispersible tablets of taste masked Ondansetron Hydrochloride being simple and cost effective. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
