| Autor: |
Sharma, Gaurav Sanjay, Pagar, Diplaxmi, Ahire, Sandip B. |
| Předmět: |
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| Zdroj: |
Pharma Science Monitor; Jan-Mar2015, Vol. 6 Issue 1, p75-93, 19p |
| Abstrakt: |
The oral route of drug administration is the most important route of drugs administering drugs for systemic effect. Tablet represent unit dosage forms in which one usual dose of drug has been accurately placed. Formulation of a convenient dosage form for administration by considering swallowing difficulty and poor patient compliance, leads to development of disintegrating tablet. Disintegrating tablet combine the advantage of both liquid and conventional tablet formulation allowing the ease of swallowing the drug in the form liquid dosage form. The basic approach to the development of disintegrating tablet is the use of superdisintegrants such as crosspovidone and sodium starch glycolate. Famotidine was used as model drug in present study because it is an antihistaminic drug that has been widely used in treating gastric and duodenal ulceration and also in zollinger ellison syndrome and reflux esophagitis. Famotidine is a H2 receptor antagonist. A thiazole ring containing H2 blocker which binds tightly to H2 receptors and exhibits longer duration of action despite elimination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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