| Autor: |
Koycheva, Y. M., Taseva, T. K., Popova, S. G., Stoimenova, D. B., Penkov, L. I. |
| Předmět: |
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| Zdroj: |
Genetics & Plant Physiology; 2015, Vol. 5 Issue 1, p86-93, 8p |
| Abstrakt: |
Genomic imprinting is an epigenetic process resulting in the monoallelic parent-of-origin-specific expression of a subset of genes in the mammalian genome. Many imprinted genes are expressed during embryo growth and are important for fetal and placental development. Progesterone is a natural steroid hormone involved in the establishment and maintenance of pregnancy. Despite the wide use of progesterone as a protecting agent against miscarriages during human pregnancy, very little is known about its effects on the developing embryo. In the present work, we investigated the effects of progesterone on the postimplantation embryo development and in particular, the expression of some growth-related imprinted genes in mice. The effect of progesterone was studied after in vivo administration (injection of pregnant mice). The expression of the imprinted genes Igf2, H19 and Grb10 was assessed by quantitative RT-PCR. Special attention was given to the placenta as it is the most likely site where progesterone would exert its effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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