| Abstrakt: |
Objective: To study the association between the volume size of single follicular and iVF-ET/ iCSi outcomes, in which the ultrasound was used to observe the single follicular developmental state in natural cycles and minimal stimulation cycles. Methods: Clinical data of 1 480 women undergoing iVF-ET/iCSi in our center between April 2007 and May 2012 were retrospectively analyzed. They were divided into 5 groups according to the follicular volume size:group A,≥ 5.5 mL;group B,4.5-5.0 mL,group C,3.5-4.0 mL,group D, 2.5-3.0 mL,group E, 1.0-2.0 mL. The clinical outcomes were compared. Results: 1Follicular volume was significantly decreased with the mean diameter of single follicle on the day of hCG administration in 5 groups, in both non-stimulation protocol and minimal stimulation protocol (P<0.001). 2In natural cycles, the pregnancy rate and live birth rate were relatively low in group A (11.8%), while those rates in other four groups were 20.0%-25.0% and 15.8%-20.0%, but there were not significant differences in groups (P >0.05). in group A,the available transplantation embryo rate was high while the non-fertilization rate was low; the zero oocyte retrieval rate(32.6%) was higher than those in group C and group D(P<0.01); the available transplantation embryo cycle was merely 39.53%(17/43). In group B,the 2PN rate was high while the abnormal fertilization and the not-done fertilization rate were low; the non-fertilization rate was relative high while the available transplantation embryo cycle was merely 48.19% (40/83). The results of other C groups were better than group A generally. 3In minimal stimulation cycles, the pregnancy rates were high in group B and C (24.1% and 21.6%), but there were not significant differences when compared with three other groups (16.7%-17.8%, P >0.05). There were significant differences in the rates of fertilization, abnormal fertilization, good embryo and available transplantation embryo among five groups (P<0.05). The abnormal fertilization rate in group B was relatively high (15.4%) and the available transplantation embryo rate and the good embryo rate were highest (97.0% and 87.8%, respectively). The good embryo rate and the available transplantation embryo rate in group E were lowest (58.1% and 75.8%, respectively,P<0.01). The fertilization rate in group C was lowest and the abnormal fertilization rate was also lowest (3.0%,P<0.01). Conclusions:IVF-ET/ICSI outcomes may be better when the volume of single follicle was 2.5-5.0 mL(15.1-19.6 mm of oocyte diameter). However, it is necessary to have more well-designed and multicenter studies. [ABSTRACT FROM AUTHOR] |
