| Autor: |
Bin Mubayrik, Azizah F., Deeley, K., Patir, A., Koruyucu, M., Seymen, F., Vieira, A. R. |
| Předmět: |
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| Zdroj: |
Journal of the Pakistan Dental Association; Apr-Jun2014, Vol. 23 Issue 2, p66-69, 4p |
| Abstrakt: |
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of the β-defensin gene DEFB1 have recently been shown to be associated with altered risk of developing caries in permanent dentition. OBJECTIVE: We therefore sought to establish whether DEFB1 SNPs conferred a similar risk in primary dentition. METHODOLOGY: DEFB1 genotypes (rs11362 and rs1800972) were studied in 178 children, of whom 92 had caries. CONCLUSION: No association between genotype and phenotype was detected, even when more severe caries was considered as the phenotype. These and other data suggest that non-genetic factors may be greater modifiers of caries risk in primary dentition. DECLARATION OF INTERESTS: There are no conflicts of interest to declare. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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