| Autor: |
Sycheva, L., Mikhailova, R., Belyaeva, N., Zhurkov, V., Yurchenko, V., Savostikova, O., Alekseeva, A., Krivtsova, E., Kovalenko, M., Ahaltseva, L., Sheremet'eva, S., Yurtseva, N., Muravyeva, L. |
| Zdroj: |
Nanotechnologies in Russia; Mar2015, Vol. 10 Issue 3/4, p311-317, 7p |
| Abstrakt: |
Mutagenic and cytotoxic effects of multiwalled carbon nanotubes (MWCNTs) and activated carbon in low doses (0.028 and 0.074 mg/kg) were studied for the first time in an experiment on mice in vivo when administered with drinking water for 2 weeks. We studied Taunit MWCNTs with an outer diameter of 15-40 nm, inner diameter of 3-8 nm, length of 2 μm or more, and specific geometrical surface of 0.4-0.5 m/g and Flotosorb A activated carbon, powdered carbon with a particle size of less than 0.1 mm. Suspensions of nanomaterials were investigated after ultrasonic homogenization using a multiorgan karyological test with an analysis of cytogenetic damages, proliferation, and apoptosis in isolated cells of several organs. The mutagenic effects of MWCNTs and active carbon were detected in cells of the forestomach and lungs, respectively. The cytotoxic effect of both substances was found in the epithelium of the forestomach, small intestine, bladder, and bone-marrow and lung cells according to changes in biomarkers of proliferation and/or destruction of the cell nucleus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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