Plasma fatty acid lipidome is associated with cirrhosis prognosis and graft damage in liver transplantation.

Autor:	Ginanni Corradini, Stefano, Zerbinati, Chiara, Maldarelli, Federica, Palmaccio, Giuseppina, Parlati, Lucia, Giulia Bottaccioli, Anna, Molinaro, Antonio, Poli, Edoardo, Boaz, Mona, Serviddio, Gaetano, Mennini, Gianluca, Corsi, Alessandro, Bianco, Paolo, Rossi, Massimo, Iuliano, Luigi
Předmět:	CIRRHOSIS of the liver THERAPEUTIC use of biochemical markers LINOLEIC acid ACADEMIC medical centers BLOOD testing CHI-squared test CLINICAL trials CONFIDENCE intervals FATTY acids LIVER transplantation NUTRITION RESEARCH funding T-test (Statistics) LOGISTIC regression analysis TREATMENT effectiveness CASE-control method DATA analysis software DESCRIPTIVE statistics ODDS ratio MANN Whitney U Test PROGNOSIS THERAPEUTICS
Zdroj:	American Journal of Clinical Nutrition; Aug2014, Vol. 100 Issue 2, p600-608, 9p, 6 Charts, 1 Graph
Abstrakt:	Background: Knowledge regarding the plasma fatty acid (FA) pattern in patients with liver cirrhosis is fragmentary. Objective: We evaluated plasma FA lipidome and its association with the prognosis of cirrhosis and severity of liver graft damage after transplantation. Design: In this observational study, plasma FA lipidome was investigated in 51 cirrhotic patients before liver transplantation and in 90 age- and sex-matched healthy control subjects. In addition, we studied ischemia-reperfusion damage in the liver of 38 patients for whom a graft biopsy was available at transplantation. With the use of logistic regression, we modeled the presence of cirrhosis, the dichotomized model for end-stage liver disease score below and above the median, and the presence of severe liver graft ischemia-reperfusion damage. Results: The FA pattern was markedly altered in cirrhotic patients, who showed, compared with healthy controls, higher monounsaturated FAs, lower n-6 and n-3 polyunsaturated FAs, and undetectable cerotic acid. Plasma di-homo-γ-linolenic acid was independently associated with the presence of cirrhosis (OR: 0.026; 95% CI: 0.004, 0.196; P < 0.0001), severity of its prognosis (OR: 0.041; 95% CI:0.005, 0.376; P = 0.006), postreperfusion graft hepatocellular necrosis (OR: 0.921; 95% CI: 0.851, 0.997; P = 0.043), and sinusoidal congestion (OR: 0.954; 95% CI: 0.912, 0.998; P = 0.039). Associations of di-homo-γ-linolenic acid with the presence of cirrhosis and severity of its prognosis were confirmed also after false discovery rate correction. Conclusions: Cerotic and di-homo-γ-linolenic acids may serve as markers of disease and prognosis in liver cirrhosis. Dietary supplementation with di-homo-γ-linolenic acid could be a reasonable interventional strategy to delay disease progression in liver cirrhosis. This trial was registered at clinicaltrials.gov as NCT01389115. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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