| Autor: |
Catley, Matthew C., Chivers, Joanna E., Cambridge, Lisa M., Holden, Neil, Slater, Donna M., Staples, Karl J., Bergmann, Martin W., Loser, Peter, Barnes, Peter J., Newton, Robert |
| Předmět: |
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| Zdroj: |
FEBS Letters; Jul2003, Vol. 547 Issue 1-3, p75, 5p |
| Abstrakt: |
Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-κB-activating stimuli interleukin-1β (IL-1β) and phorbol 12-myristate 13-acetate (PMA). Adenoviral over-expression of IκBαΔN, a dominant NF-κB inhibitor, prevents NF-κB-dependent transcription and was used to qualify the role of NF-κB in the release of PGE2. IκBαΔN repressed IL-1β-induced, but not PMA-induced, cycloxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) expression. These data conclusively demonstrate a substantial role for NF-κB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1β. However, other pathways are primarily responsible for PGE2 release induced by PMA. [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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