Clinical predictors and time course of the improvement in β-cell function with short-term intensive insulin therapy in patients with Type 2 diabetes.
Autor: | Stein, C. M., Kramer, C. K., Zinman, B., Choi, H., Opsteen, C., Retnakaran, R. |
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Předmět: |
TYPE 2 diabetes treatment
PANCREATIC physiology BLOOD pressure BLOOD pressure measurement CELL physiology CONFIDENCE intervals CREATININE PEOPLE with diabetes DIET ETHNIC groups FASTING FISHER exact test GLYCOSYLATED hemoglobin INSULIN LIVER function tests EVALUATION of medical care TYPE 2 diabetes DATA analysis ALANINE aminotransferase BODY mass index ACQUISITION of data DISEASE remission METFORMIN DISEASE duration DATA analysis software THIAZOLIDINEDIONES WAIST circumference ODDS ratio |
Zdroj: | Diabetic Medicine; May2015, Vol. 32 Issue 5, p645-652, 8p, 2 Charts, 2 Graphs |
Abstrakt: | Aims In patients with Type 2 diabetes, a short course of intensive insulin therapy can improve β-cell function and even induce transient remission of diabetes. However, not all patients respond to this therapy. Although the achievement of fasting glucose < 7.0 mmol/l one day after stopping intensive insulin therapy can identify patients in whom β-cell function has improved, we sought to determine clinical predictors for the early identification of such responders and the time course of response. Methods We pooled data from two studies in which 97 patients with Type 2 diabetes mellitus (median 3 years duration) and HbA |
Databáze: | Complementary Index |
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