Selectable System for Monitoring the Instability of CTG/CAG Triplet Repeats in Mammalian Cells.

Autor: Gorbunova, Vera, Seluanov, Andrei, Dion, Vincent, Sandor, Zoltan, Meservy, James L., Wilson, John H.
Předmět:
Zdroj: Molecular & Cellular Biology; Jul2003, Vol. 23 Issue 13, p4485, 9p, 8 Diagrams, 3 Charts, 1 Graph
Abstrakt: Develops a selectable assay to detect contractions of CTG/CAG trinucleotide repeats. Incorporation of CTG/CAG repeats into messenger RNA as an exon; Effect of the repeats on the encoded protein; Determination of the frequency of spontaneous contractions.
Databáze: Complementary Index