| Autor: |
Jambor, Ivan, Kähkönen, Esa, Taimen, Pekka, Merisaari, Harri, Saunavaara, Jani, Alanen, Kalle, Obsitnik, Branislav, Minn, Heikki, Lehotska, Viera, Aronen, Hannu J. |
| Zdroj: |
Journal of Magnetic Resonance Imaging; May2015, Vol. 41 Issue 5, p1394-1404, 11p |
| Abstrakt: |
Purpose To find the diagnostic accuracy of 3T multiparametric magnetic resonance imaging (mpMRI) and mpMRI targeted transrectal ultrasound (TRUS)-guided biopsy using visual coregistration (TB) in patients with elevated prostate-specific antigen (PSA), normal digital rectal examination, and no previous biopsy. Materials and Methods Fifty-five patients at two institutions underwent mpMRI, consisting of anatomical T2-weighted imaging ( T2W), diffusion-weighted imaging (DWI), proton magnetic resonance spectroscopy (1H-MRS), and dynamic contrast-enhanced MRI (DCE-MRI), followed by TB in addition to 12 core systematic TRUS-guided biopsy (SB). Histopathological scorings of biopsy ( n = 38) and prostatectomy ( n = 17) specimens were used as the reference standard for calculation of diagnostic accuracy values. Clinically significant prostate cancer (SPCa) was defined as 3 mm core length of Gleason score 3+3 or any Gleason grade 4. Results The sensitivity, specificity, accuracy, and area under the curve (AUC) values for the detection of SPCa on the sextant level for T2W+DWI+1H-MRS+DCE-MRI were 72%, 89%, 85%, and 0.81, respectively. The corresponding values for T2wi+DWI were 61%, 96%, 87%, and 0.79, respectively. The overall PCa detection rate per core in 53 patients was 21% (138 of 648 cores) for SB and 43% (33 of 77 cores) for TB ( P < 0.001). Conclusion Prebiopsy mpMRI is an accurate tool for PCa detection and biopsy targeting in patients with elevated PSA. J. Magn. Reson. Imaging 2015;41:1394-1404. © 2014 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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