| Autor: |
Melik-Ohanjanyan, R., Hovsepyan, T., Israelyan, S., Ghukasyan, M., Karakhanyan, G., Panosyan, H., Tamazyan, R., Ayvazyan, A. |
| Předmět: |
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| Zdroj: |
Russian Journal of Organic Chemistry; Mar2015, Vol. 51 Issue 3, p361-367, 7p |
| Abstrakt: |
New acyclic pyrimidine nucleosides, analogs of the antiviral drug acyclovir, were synthesized starting from 6-chloropyrimidine-2,4(1 H,3 H)-dione. The addition of side carbohydrate chain to the N or N atoms of the heterocyclic base with formation of N- and N-substituted isomers, respectively, was confirmed by H NMR and X-ray analysis. N- and N-Substituted 6-chloropyrimidine-2,4(1 H,3 H)-diones were subjected to amination with secondary amines, and cyclocondensation of 6-allylamino derivative afforded N-substituted pyrido[2,3- d]pyrimidine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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