Autor: |
Yudkin, D., Lemskaya, N., Grischenko, I., Dolskiy, A. |
Předmět: |
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Zdroj: |
Molecular Biology; Mar2015, Vol. 49 Issue 2, p179-184, 6p |
Abstrakt: |
Fragile X syndrome is an inherited neurodegenerative disease with a frequency of 1/4000-1/6000. It is the main cause of inheritable mental retardation. The progression of the disorder is caused by CGG repeat expansion in 5′ UTR of fmr1 (fragile X mental retardation 1) gene. The normal allele contains ≤ 54 repeats. Alleles containing 55-200 repeats induce fragile X-associated disorders: fragile X-associated tremor/ataxia syndrome and fragile-X associated primary ovarian insufficiency. Alleles containing ≤ 200 repeats induce fragile X syndrome. The absence of FMRP protein is the main reason for the progression of the syndrome. FMRP is RNA-binding protein responsible for neuronal differentiation. In case of increasing CGG triplets number the expression of fmr1 gene is repressed. Results of CGG expansion are DNA methylation, histone methylation and deacetylation. Repression transcription factors bind this chromatin and lead to the progression of the disorder. In this review, we discuss how heterochromatinization is induced by CGG repeat expansion in the promoter region of fmr1 gene. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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