| Abstrakt: |
Introduction. The question of drawing new types of alcoholic beverages with reduced toxicity. The aim was to determine the histological characteristics of the structure of the liver when administered to Wistar rats of different types of alcoholic liquors with low toxicity. Materials and Methods. The experiment used four groups of animals that used different types of liquors developed. Microscopy made on microscope Axiostar-plus, photography - the camera Progress C10. On the computer image micropreparations held kartometriya ("VideoTest"). Results and discussion. The degree of liver damage in rats of different groups in the use of experimental infusions. Determined that the area of intact nuclei hepetotsytiv an average of 32,70 ± 0,78 um2. In intact animals trabeculae level, the lumen of sinusoids is absent, the cytoplasm is compact (less enlightened) and contains little glycogen. In animals, the first main group (40% of long term use of water-alcohol mixture) revealed histological features of alcoholic liver disease with the formation of various animals in this group of chronic hepatitis varying degrees of activity. Hepatocytes have large nucleus, an area of 43,25 ± 1,1mkm2. In the second study group (40% of long term use of water-alcohol mixture with the addition of plant material) structure of the liver is preserved, distinct trabeculae, education sinusoids visible. The nuclei of hepatocytes have a slightly smaller footprint compared to the first main group 38,8 ± 1,05 um2. In the third main group (prolonged consumption of 40% alcohol mixture with the addition of vegetable and animal raw materials) histostructure liver preserved, trabeculae level, the presence of foci of cytolysis of hepatocytes were observed. The nuclei of hepatocytes have a minimum area of 33,57 ± 0,91 um2 compared to other major groups; value of this indicator unreliable different from the group of intact animals. It is proved that the addition of a mixture of plant and animal products improved morphofunctional state of the liver in the absence of background lesions cytolysis of hepatocytes and hepatocyte nuclei normalization value. Conclusions. Developed alcohol tinctures reduce the toxic effects of alcohol on the liver. [ABSTRACT FROM AUTHOR] |
