| Abstrakt: |
Objective To evaluate the efficacy and safety of modified standard chemotherapy in the treatment of spinal tuberculosis, and clarify the common side effects as well as corresponding treating measures. Methods From 2008 January to 2012 December, cases of spinal tuberculosis were collected in our hospital, received the modified standard chemotherapy (2HRZE/4HRE/12-18HR;H 300mg R dose, 450 mg, Z 750 mg, E 750mg, meal served in morning), and followed up for at least 2 years. The chemotherapy efficacy was evaluated using the clinical cure rate and recurrence rate. Meanwhile, the chemotherapy safety was evaluated through the drug side effect incidence and severity. The drug side effects were analyzed by statistics according to the types, duration, severity, and treatment measures. Results A total of 67 patients were included in the study, including 32 cases of male, 35 cases of female; aged 15-68 years (mean, 40. 6 years) . 21 patients were treated with modified standard chemotherapy, the remaining 46 cases were treated with preoperative chemotherapy + operation + chemotherapy after surgery. The clinical healing rate within 2 years was 95. 52%, and the recurrence rate after 2 years was 1. 50% . In the whole period of chemotherapy, drug side effects occurred mainly in intensive treatment period in the first 2 months, mainly related to the gastrointestinal reaction (about 28.36%), hyperuricemia (about 31.34%) and abnormal liver function (about 31.34%), but most drugs had mild side effects. In some cases with serious liver injury, liver protecting drugs (such as polyene phosphatidyl choline, glyphosate acid two sodium or glutathione etc.), sodium bicarbonate and drinking more water measures were verified as effective. The removal of pyrazinamide might reduce the incidence of hyperuricemia. Conclusion The use of modified standard chemotherapy for the treatment of spinal tuberculosis has a good clinical curative effect with high security. [ABSTRACT FROM AUTHOR] |
