| Autor: |
Limonard, E.J., Schoor, N.M., Jongh, R.T., Lips, P., Fliers, E., Bisschop, P.H. |
| Předmět: |
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| Zdroj: |
Clinical Endocrinology; May2015, Vol. 82 Issue 5, p753-759, 7p, 4 Charts |
| Abstrakt: |
Objective Osteocalcin is a well-known marker of bone formation. Recently, mice lacking osteocalcin or its receptor were reported to be subfertile with low testosterone and high luteinizing hormone concentrations. In parallel, in humans, a loss-of-function mutation of the osteocalcin receptor was associated with hypergonadotropic hypogonadism. This suggests that osteocalcin is necessary for normal pituitary-gonadal axis function. Our objective was to determine the association between physiological variations in osteocalcin and the pituitary-gonadal axis in older men. Design and patients Data were used from the Longitudinal Aging Study Amsterdam ( LASA), an ongoing cohort study in a representative sample of the older Dutch population (65-88 years). Measurements Serum levels of total (T), free ( FT) and bioavailable (bioT) testosterone, luteinizing hormone ( LH) and osteocalcin were determined. Data were analysed using linear regression analyses and adjusted for age, BMI, 25-hydroxyvitamin D, parathyroid hormone and vitamin K antagonist use. Results A total of 614 men participated in the study. The median age was 75·4 (69·8-81·2) years, and the median osteocalcin level was 1·8 (1·3-2·4) nmol/l. Serum osteocalcin was inversely associated with FT (adjusted B = −0·22 ± 0·09 ng/dl, P = 0·012) and bioT (adjusted B = −0·26 ± 0·08 nmol/l, P < 0·01), but not with total T. Furthermore, osteocalcin was positively associated with LH (adjusted B = 0·09 ± 0·03 U/l, P < 0·01). Conclusions Serum osteocalcin was negatively associated with free and bioavailable testosterone and positively with luteinizing hormone levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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