| Autor: |
Saravanan, M., Alexander, S., Matthai, S. M., Korula, A., Varughese, S., Tamilarasi, V. |
| Předmět: |
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| Zdroj: |
Indian Journal of Nephrology; Mar/Apr2015, Vol. 25 Issue 2, p113-116, 4p, 1 Color Photograph, 1 Black and White Photograph, 2 Charts |
| Abstrakt: |
Immunoglobulin G4-related disease (IgG4-RD) is an emerging clinicopathological entity. Renal involvement is dominated by tubulointerstitial nephritis (TIN) with IgG4‑positive plasma cells and fibrosis. IgG4‑RD commonly affects middle‑aged to elderly men with accompanying extra-renal lesions such as sialadenitis, lymphadenopathy, or type 1 autoimmune pancreatitis, all of which respond favorably to corticosteroid therapy. The disease burden of IgG4-related kidney disease (IgG4-RKD) in India remains largely underestimated. We report a case of IgG4-RKD manifesting as TIN associated with interstitial pulmonary disease, illustrating typical clinico-pathologic, serologic, immuno-histochemical, and ultrastructural features of this condition. In view of potential amelioration of renal dysfunction with appropriate therapy, the need for awareness of this condition and early diagnosis is highlighted. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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