| Autor: |
SRINIVAS, P., MANJUNATH, C. N., BANU, SHAHEENA, RAVINDRANATH, K. S. |
| Předmět: |
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| Zdroj: |
Journal of Clinical & Diagnostic Research; Sep2014, Vol. 8 Issue 9, p1-6, 6p |
| Abstrakt: |
Background: Heart failure (HF) is a growing public health problem. Patients often present to emergency department (ED) with acute onset dyspnea where a rapid triage is required to avoid misdiagnosis and to institute appropriate therapy. An objective risk-stratification in the ED is warranted to identify patients at high risk of adverse outcomes, so that more intensive therapy and vigilant follow-up after discharge are instituted. Methods and Results: Fifty two consecutive acute HF (AHF) patients in NYHA class lll/IV were enrolled for the present study. N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hsTropT), high-sensitivity C-reactive protein (hsCRP) and Uric acid (UA) were evaluated at admission; a second sample for NT-proBNP and hsTropT was obtained 48h later. The end-point of the study, a composite of cardiovascular death, rehospitalisation for worsening HF symptoms and refractory HF was reached in 32.7% of patients during a median follow-up of 4.8mnth. Although, hsTrof (>0.014ng/ml),hsCRP(>0.5mg/dl)andUA(>5.6mg/dlforfemal< and >7 mg/dl for males) were elevated in the vast majority patients (92.3%, 75% and 63.5% respectively), baseline ar changing patterns of NT-proBNP following treatment were tl only predictors of adverse outcomes on follow-up. A significa correlation between hsTropT, hsCRP and UA was observs suggesting a link between inflammation, myocyte injury ar oxidative stress in AHF. Conclusion: Baseline and changing patterns of NT-proBr> predicted adverse outcomes on follow-up suggesting that strategy of serial measurement of NT-proBNP could pro' invaluable in early risk stratification. Further research is needs to understand the link between inflammation, myocyte inju and oxidative stress in AHF which could provide potent therapeutic targets. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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