Effect of dimeric netropsin analogue 15Lys-bis-Nt and acyclovir on the reproduction of herpes simplex virus type 1. The search for variants of herpes virus with drug resistance to 15Lys-bis-Nt and acyclovir.

Autor: Andronova, V., Grokhovsky, S., Surovaya, A., Gursky, G., Galegov, G.
Předmět:
Zdroj: Doklady Biochemistry & Biophysics; Jan2015, Vol. 460 Issue 1, p42-46, 5p
Abstrakt: The article presents a study which examines the antiviral activity of dimeric netropsin derivative 15Lys-bis-Nt used in combination with herpes infection treatment drug acyclovir (ACV). The study used a multiciplity of infection (MOI) and demonstration of the international guidelines on ACV as treatment and prevention of recurrences of genital herpes. The study conclude the use of 15Lys-bis-Nt did not yield a drug-resistant with HSV-1 variant.
Databáze: Complementary Index