| Autor: |
Carrasco, X., López, V., Huerta, D., Rothhammer, P., Daiber, F., Bustamante, J., Zamorano, F., Henríquez, H., Jeldres, E., Figueroa, J. P., Tirado, K., Reinbach, K., Pérez, P., Legüe, M., López, J., Cosmelli, D., Devilat, M., Rothhammer, F., Aboitiz, F. |
| Zdroj: |
European Child & Adolescent Psychiatry; Jun2010, Vol. 19, pS69-S69, 1/5p |
| Abstrakt: |
Introduction: Not all ADHD subjects respond equally to stimulants Methods: We analyzed the clinical response, CPT performance and DAT1 polymorphism of 73 ADHD patients 8–14 years of age (13 girls) after 1 year of stimulant treatment. Results: (1) A positive correlation between CPT performance and clinical response; (2) clinical response depends on comorbidities while CPT performance does not; (3) the clinically responding group shows a higher IQ than the nonresponding group; (4) children displaying little improvement in the CPT test after treatment have a higher frequency of the DAT1 9R allele (χ2 p 0.02); but clinical response is independent of DAT1 polymorphism. Conclusion: CPT and genetics are good predictors of stimulant response. FONDECYT 1070761 and 1080219. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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