| Autor: |
Tsung Wen Chong, Fera Yiqian Goh, Mei Yi Sim, Hong Hong Huang, Daw Aye Aye Thike, Weng Khong Lim, Bin Tean Teh, Puay Hoon Tan |
| Předmět: |
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| Zdroj: |
Journal of Clinical Pathology; Mar2015, Vol. 68 Issue 3, p200-205, 6p |
| Abstrakt: |
Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ²/ Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan-Meier method and compared using Cox regression analysis. Results Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/ grade, higher relapse rates, poorer cancer-specific and overall survival. Conclusions CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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