4-Trimethylsilyl-5-iodo-1,2,3-triazole: A Key Precursor for the Divergent Syntheses of 1,5-Disubstituted 1,2,3-Triazoles.

Autor:	Lingjun Li, Tongpeng Shang, Xiaonan Ma, Haiyun Guo, Anlian Zhu, Guisheng Zhang
Předmět:	TRIMETHYLSILYL compounds TRIAZOLES CHEMICAL synthesis BIFUNCTIONAL catalysis CUPROUS iodide COPPER catalysts PALLADIUM catalysts
Zdroj:	Synlett; 2015, Vol. 26 Issue 5, p695-699, 5p
Abstrakt:	Bifunctional 4-trimethylsilyl-5-iodo-1,2,3-triazoles (TMSIT) were reported in this paper, which could be efficiently synthesized directly from readily accessible TMS-alkyne, azide, and copper(I) iodide at room temperature. Using TMSIT as key precursors, a divergent protocol for the preparation of 1,5-disubstituted 1,2,3-triazoles was developed via sequential copper/palladium-catalyzed coupling reactions and desilylation in one pot. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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