| Autor: |
Chiaravalloti, Agostino, Pagani, Marco, Micarelli, Alessandro, Pietro, Barbara, Genovesi, Giuseppe, Alessandrini, Marco, Schillaci, Orazio |
| Předmět: |
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| Zdroj: |
European Journal of Nuclear Medicine & Molecular Imaging; May2015, Vol. 42 Issue 5, p733-740, 8p, 2 Diagrams, 5 Charts |
| Abstrakt: |
Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals. Methods: Two F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in F-FDG uptake were analysed by statistical parametric mapping (SPM2). Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10. Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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