Low serum level of 1,25( OH)2D is associated with chronic periodontitis.

Autor:	Antonoglou, G. N., Knuuttila, M., Niemelä, O., Raunio, T., Karttunen, R., Vainio, O., Hedberg, P., Ylöstalo, P., Tervonen, T.
Předmět:	CHRONIC disease risk factors PERIODONTITIS ACADEMIC medical centers BLOOD testing CONFIDENCE intervals INFLAMMATION LONGITUDINAL method RESEARCH funding STATISTICS VITAMIN D VITAMIN D deficiency LOGISTIC regression analysis DATA analysis CASE-control method DATA analysis software DESCRIPTIVE statistics ODDS ratio DISEASE complications DISEASE risk factors
Zdroj:	Journal of Periodontal Research; Apr2015, Vol. 50 Issue 2, p274-280, 7p, 3 Charts
Abstrakt:	Background and Objectives Vitamin D has been studied primarily for its involvement in calcium and phosphate absorption and bone metabolism. The active form of vitamin D-1,25( OH)2D-has also been investigated for its immune modulatory properties. We explored associations between serum levels of 25( OH)D and 1,25( OH)2D and periodontal health. Subjects and Methods This case-control study included 55 subjects with chronic periodontitis (cases) and 30 periodontally healthy subjects (controls). Their serum levels of 25( OH)D, 1,25( OH)2D, ultrasensitive C-reactive protein and high-density lipoprotein cholesterol were determined. Associations between vitamin D and periodontal health status were studied using logistic regression analysis. Results A statistically significant association was found between serum 1,25( OH)2D level and periodontal health status; in that subjects with a low 1,25(OH)2D were more likely to belong to the periodontitis group ( OR = 0.97, 95% CI = 0.95-1.00). There was practically no association between 25( OH)D level and periodontal health status. Conclusion In this case-control study low serum 1,25( OH)2D level appeared to be associated with periodontitis, which was in line with the previously reported associations between serum 1,25(OH)2D levels and other inflammatory diseases. Whether this association is causal in nature, remains to be confirmed in future studies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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