Clinicopathological Features and Prognostic Significance of HER2 Expression in Gastric Cancer.
| Autor: | Park, Ji Soo, Rha, Sun Young, Chung, Hyun Cheol, Jung, Minkyu, Kim, Ki Hyang, Jun, Hyun Jung, Kim, Hyunki, An, Ji Yeong, Kim, Hyoung-Il, Cheong, Jae-Ho, Hyung, Woo Jin, Noh, Sung Hoon, Kim, Hyo Song |
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| Předmět: |
STOMACH tumors
ACADEMIC medical centers CHI-squared test CONFIDENCE intervals FISHER exact test MULTIVARIATE analysis ONCOGENES RESEARCH funding STATISTICS SURVIVAL FLUORESCENCE in situ hybridization LOGISTIC regression analysis PROPORTIONAL hazards models DESCRIPTIVE statistics KAPLAN-Meier estimator LOG-rank test ODDS ratio PROGNOSIS |
| Zdroj: | Oncology; Feb2015, Vol. 88 Issue 3, p147-156, 10p, 3 Charts, 3 Graphs |
| Abstrakt: | Background: HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. Methods: A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included in this study. Results: Ninety-five (11.7%) patients had HER2-positive gastric cancer. Elevated serum carcinoembryonic antigen (CEA) concentration [odds ratio (OR), 5.629; p < 0.001] and differentiated histology (OR, 3.717; p = 0.002) were significant predictive factors for HER2 positivity in localized disease. For recurrent or metastatic disease, elevated serum CEA concentration (OR, 2.545; p < 0.001), differentiated histology (OR, 3.299; p < 0.001), pulmonary metastasis (OR, 3.321; p = 0.001), and distant lymph node metastasis (OR, 2.286; p = 0.002) were significant predictive factors. Median disease-free survival (DFS) was shorter in HER2-positive patients than in others, especially in stage I or II disease (24.7 vs. 49.2 months; p < 0.001). Among HER2-negative patients with stage II diseases, patients who received adjuvant chemotherapy had longer DFS than others (42.2 vs. 30.7 months; p = 0.025). Conclusions: Clinicopathological factors may be useful in predicting the HER2 positivity of gastric cancer. Further studies are needed to understand the molecular basis of HER2-positive gastric cancer. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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