Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer.

Autor: Wang, Xiao-Lin, Xie, Hu-Yang, Zhu, Chuan-Dong, Zhu, Xiao-Fang, Cao, Guang-Xin, Chen, Xiao-Hong, Xu, Han-Feng
Zdroj: Tumor Biology (Springer Science & Business Media B.V.); Feb2015, Vol. 36 Issue 2, p877-883, 7p
Abstrakt: The aims of this study are to analyze the association of microRNA-141 (miR-141) with the clinicopathological parameters of bladder cancer and evaluate the value of miR-141 in predicting the prognosis of bladder cancer. In this study, 114 patients with bladder cancer were enrolled in the study, and tissue specimens were obtained from the tumor zone and from adjacent normal area. miR-141 expression was determined using SYRB Green quantitative real-time polymerase chain reaction assay and was further correlated with patients' clinicopathological parameters and the follow-up data. The results indicated that miR-141 was upregulated in malignant bladder specimens compared with normal ones ( P < 0.001). miR-141 expression was significantly associated with tumor stage ( P < 0.001), tumor grade ( P < 0.001), and muscle invasion status ( P < 0.001). Log-rank test showed that the higher miR-141 expression was associated with longer disease-specific survival of the patients with bladder cancer ( P < 0.001), which was also proven by univariate and multivariate Cox regression analysis ( P < 0.001 and P = 0.039, respectively). Focusing on patients with non-muscle invasive bladder cancer, univariate analysis using log-rank test and Cox regression analysis found that patients with high miR-141 expression experienced longer disease-free survival ( P = 0.031 and P = 0.040, respectively) and disease-specific survival ( P = 0.028 and P = 0.038, respectively), which was confirmed by multivariate Cox regression analysis ( P = 0.036 and P = 0.042, respectively). In conclusion, this study showed that miR-141 may contribute to the progression of bladder cancer and its upregulation may be independently associated with favorable prognosis of bladder cancer, suggesting that miR-141 might serve as a promising biological marker for further risk stratification in the management of bladder cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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