Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)4P(OEt)3](PF6)3.

Autor: Pereira, José Clayston Melo, Souza, Maykon Lima, Franco, Douglas Wagner
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Zdroj: European Journal of Inorganic Chemistry; Feb2015, Vol. 2015 Issue 6, p1005-1011, 7p
Abstrakt: The reaction between the trans-[RuNO(NH3)4P(OEt)3](PF6)3 and L-cysteine (RS-) was studied over a pH range of 2.0-7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [ k1 = (3.5 ± 0.3) × 103 M-1 s-1, pH = 3.5, 25 °C] and resulted in the formation of trans-[Ru(NH3)4P(OEt)3N(O)SR]2+, which dissociated to yield trans-[Ru(NH3)4P(OEt)3NO ·]2+ and RS ·. However, trans-[Ru(NH3)4P(OEt)3N(O)SR] n-1 can react with a second L-cysteine, yielding trans-[Ru(NH3)4P(OEt)3N(O)(SR)2]+ [ k2 = (3.6 ± 0.1) M-1 s-1, pH = 3.5, 25 °C]. Therefore, the trans-[Ru(NH3)4P(OEt)3NO ·]2+ species released NO and the trans-[Ru(NH3)4P(OEt)3N(O)(SR)2] n-2 species released HNO. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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