Glatiramer Acetate-Associated, CD30+, Primary, Cutaneous, Anaplastic Large-Cell Lymphoma.

Autor: Madray, Monica M., Greene Jr, John F., Butler, David F.
Zdroj: Archives of Neurology; Oct2008, Vol. 65 Issue 10, p1378-1379, 2p
Abstrakt: Objective: To report the association of the development of a primary, cutaneous, anaplastic large-cell lymphoma after initiation of glatiramer acetate treatment of a patient with relapsing-remitting multiple sclerosis. Design: Case report. Setting: Dermatology outpatient clinic. Patient: A 33-year-old white woman developed an erythematous nodule on her leg 4 months after starting treatment with glatiramer acetate. Biopsy showed primary, cutaneous, anaplastic large-cell lymphoma. Further evaluation showed no systemic involvement. Intervention: Radiation therapy induced a complete remission. Conclusions: Several T-cell-mediated skin conditions have been associated with the use of glatiramer acetate, such as pseudolymphoma, drug eruptions, and erythema nodosum. We report the association of a T-cell malignancy with the use of glatiramer acetate. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index