| Autor: |
Saify, Zafar Saied, Mallick, Tabinda Zarreen, Begum, Nasreen, Yousuf, Samar, Ghufran Saeed, Syed Muhammad, Haider, Shazia, Ashraf, Seema, Qaiser, Shama |
| Předmět: |
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| Zdroj: |
Defence Journal; Jan2015, Vol. 18 Issue 6, p1145-1149, 5p |
| Abstrakt: |
Protozoan parasites of the Leishmania genus are the main cause of vector-borne disease leishmaniasis throughout the world. It is caused by at least 17 different species of protozoan Leishmania and transmitted by the bite of infected sand flies. Leishmaniasis could be fatal. Present drugs have limitations to cure it due to the development of drug resistance. Hence, to design an effective leishmanicidal agent would be of great interest. Benzimidazolinyl piperidine has served as potential target due to a vast range of biological activities. In the present study a new 4-(2-keto-1- benzimidazolinyl)piperidine derivative, 1-(2-(4-fluorophenyl)-2-oxoethyl)-4-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-1-yl)piperidinium bromide has been synthesized and characterized by X-ray crystallography, 1D and 2D NMR spectroscopy. Evaluation by in vitro leishmanicidal assay showed good activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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