Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination.

Autor: Nguyen, Tuan Minh, Duong, Hung A., Richard, Jean-Alexandre, Johannes, Charles William, Pincheng, Fu, Kwong Jia Ye, Danson, Shuying, Eileen Lau
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Zdroj: Chemical Communications; 2013, Vol. 49 Issue 90, p10602-10604, 3p
Abstrakt: Cascade fluorofunctionalisation of 2,3-unsubstituted indoles featuring the formation of C–C, C–F and C–O bonds via electrophilic fluorination using N-fluorobenzenesulfonimide is described. The use of an O-nucleophile tethered to the nitrogen of indoles enables the synthesis of polycyclic fluorinated indoline derivatives from simple precursors in 40–63% yields. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index