Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface.

Autor: Ueno, Yuko, Furukawa, Kazuaki, Matsuo, Kota, Inoue, Suzuyo, Hayashi, Katsuyoshi, Hibino, Hiroki
Předmět:
Zdroj: Chemical Communications; 2013, Vol. 49 Issue 88, p10346-10348, 3p
Abstrakt: We designed a biomolecular probe for highly sensitive protein detection by modifying an aptamer with a DNA spacer. The spacer controls the distance between a fluorescence dye and a quencher, which is crucial for FRET-based sensors. We successfully demonstrated an improvement in the sensitivity of an on-chip graphene oxide aptasensor. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index