2′,4′-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in a parallel-motif DNA triplex.

Autor:	Hari, Yoshiyuki, Akabane, Masaaki, Obika, Satoshi
Předmět:	DNA PYRROLIDINE NUCLEIC acids HETEROCYCLIC compounds CHEMICAL synthesis
Zdroj:	Chemical Communications; 2013, Vol. 49 Issue 67, p7421-7423, 3p
Abstrakt:	In order to expand the target sequence used in triplex DNA formation, seven novel nucleotide analogues were synthesized and incorporated into triplex-forming oligonucleotides by post-elongation modification approaches. Among them, GPB, equipped with a suitable restricted conformation of sugar and nucleobase moieties, was found to have the highest sequence-selectivity and affinity towards CG base pairs within double-stranded DNA. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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