| Autor: |
Chirica, Mircea, Scatton, Olivier, Massault, Pierre-Philippe, Aloia, Thomas, Randone, Bruto, Dousset, Bertrand, Legmann, Paul, Soubrane, Olivier |
| Zdroj: |
Archives of Surgery; Jun2008, Vol. 143 Issue 6, p538-543, 6p |
| Abstrakt: |
Hypothesis: A subset of patients with stage IVA hepatocellular carcinoma (HCC) and preserved liver function may benefit from hepatic resection. Design: Retrospective review of a prospectively collected database. Setting: An academic tertiary care hepatobiliary unit. Patients: Twenty patients who underwent surgical treatment for stage IVA HCC between July 1998 and October 2004 were identified from the database. Intervention: Intraoperative ablation of HCC nodules was combined with resection in 6 patients (30%) to increase resectability. Three patients also underwent resection of extrahepatic tumors. Five patients (25%) had macroscopic invasion of the portal vein and 2 patients (10%) underwent thrombectomy of the vena cava. Main Outcome Measures: Intraoperative data, recurrence, and long-term survival rates were analyzed. Results: Postoperative mortality and morbidity were 5% and 30%, respectively. The median number of resected tumors per patient was 3, and the median diameter of the largest tumor was 60 mm. With a median follow-up of 23 months, 14 patients (70%) developed recurrence. Treatment of recurrence was possible in 10 patients and included transarterial chemoembolization in 7 patients (35%), of whom 2 (10%) had radiofrequency ablation first, and systemic chemotherapy in 3 patients (15%). Median survival time was 32 months, and the actuarial 1-, 3-, and 5-year survival rates were 73%, 56%, and 45%, respectively. Conclusions: Long-term survival can be achieved using an aggressive surgical approach in select patients with advanced HCC. Patients with stage IVA HCC should be followed up by a multidisciplinary team because recurrence is common and sequential treatments may prolong survival. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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