| Autor: |
Freitas, Wladimir, Quaglia, Luiz, Santos, Simone, Paula, Rafaela, Santos, Raul, Blaha, Michael, Rivera, Juan, Cury, Ricardo, Blumenthal, Roger, Nadruz-Junior, Wilson, Agatston, Arthur, Figueiredo, Valeria, Nasir, Khurram, Sposito, Andrei |
| Předmět: |
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| Zdroj: |
Aging Clinical & Experimental Research; Feb2015, Vol. 27 Issue 1, p61-67, 7p |
| Abstrakt: |
Aim of the study: Although low-density lipoprotein cholesterol (LDL-C) has been consistently demonstrated a predictor of atherosclerotic disease in a large spectrum of clinical settings, among individuals aged of 80 years or older this concept is uncertain. This study was evaluated in a carefully selected population if the association between LDL-C and coronary atherosclerotic burden remains significant in the very elderly. Methods: Individuals aged of 80 years or older ( n = 208) who spontaneously sought primary prevention care and have never manifested cardiovascular disease, malnutrition, neoplastic or consumptive disease were enrolled for a cross-sectional analysis. Medical evaluation, anthropometric measurements, blood tests and cardiac computed tomography were obtained. Results: In analyses adjusted for age, gender, diabetes, systolic and diastolic blood pressure, smoking and statin therapy, no association was found between coronary calcium score (CCS) and LDL-C [1.79 (0.75-4.29)]. There was no association between triglycerides and CCS. The association between high-density lipoprotein cholesterol (HDL-C) and CCS was significant and robust in unadjusted [0.32 (0.15-0.67)] as well as in the fully adjusted analysis [0.34 (0.15-0.75)]. Conclusion: The present study confirms in a healthy cohort of individuals aged of 80 years or more that while the association between LDL-C and coronary atherosclerosis weakens with aging, the opposite occurs with the levels of HDL-C. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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