| Autor: |
Calamai, Elisa, Dall'Angelo, Sergio, Koss, David, Domarkas, Juozas, McCarthy, Timothy J., Mingarelli, Marco, Riedel, Gernot, Schweiger, Lutz F., Welch, Andy, Platt, Bettina, Zanda, Matteo |
| Předmět: |
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| Zdroj: |
Chemical Communications; 2013, Vol. 49 Issue 8, p792-794, 3p |
| Abstrakt: |
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(ii) indicator. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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