| Autor: |
LIN GAO, TAO ZHU, GUILIN XIE, XIANGXIN LOU, SHIBAO LI, YAN ZHOU, ZHENXU DENG, DECHANG CHU, JIYU LOU, DONGSHU DU |
| Předmět: |
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| Zdroj: |
Molecular Medicine Reports; 2015, Vol. 11 Issue 2, p1057-1062, 6p |
| Abstrakt: |
Excessive activation of the greater splanchnic nerve (GSN) has previously been determined to contribute to the progression of gastric ischemia-reperfusion (GI-R) injury. The present study was designed to estimate the protective effects of GABAA receptor (GABAAR) overexpression in the lateral hypothalamic area (LHA) against GI-R injury. The GI-R injury model was induced in rats by clamping the celiac artery for 30 min and then reperfusing for 1 h. Microinjection of recombinant adenoviral vectors overexpressing GABAAR (Ad-GABAAR) or control adenoviral vectors (Ad-Con) into the LHA was conducted in GI-R and normal control rats. Significant protective effects were observed on day 2 after Ad-GABAAR treatment in the GI-R injury rats. Ad-GABAAR treatment reduced plasma norepinephrine levels, plasma angiotensin II levels and peripheral GSN activity, but increased the gastric mucosal blood flow, as compared with Ad-Con treatment. These results indicate that adenoviral vector-induced GABAAR overexpression in the LHA blunts GSN activity and subsequently alleviates the effects of gastric injury in GI-R rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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