Proline-Catalyzed α-Aminooxylation of β-Amino Aldehydes: Access to Enantiomerically Pure syn- and anti-3-Amino-3-aryl- 1,2-alkanediols.

Autor: Venkataramasubramanian, V., I. N. Chaithanya Kiran, Sudalai, Arumugam
Předmět:
Zdroj: Synlett; 2015, Vol. 26 Issue 3, p355-358, 4p
Abstrakt: A new synthetic method for enantioselective synthesis of syn or anti-3-amino-3-aryl-1,2-alkanediols via proline catalyzed α-aminooxylation of β-amino aldehydes are described. This methodology is successfully applied to a concise and protecting group-free asymmetric synthesis of (-)-cytoxazone, (+)-epi-cytoxazone and formal synthesis of N-thiolated 2-oxazolidinone. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index