Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma.

Autor:	Han, Lu, Sun, Lingling, Zhao, Zhenzhen, Chao, Yan, Sun, Zhifu, Li, Hui, Luo, Bing
Předmět:	NASOPHARYNX cancer NUCLEOTIDE sequence EPSTEIN-Barr virus LYMPHOMAS HUMAN genetic variation GENETIC polymorphisms IMMUNOSUPPRESSION
Zdroj:	Archives of Virology; Feb2015, Vol. 160 Issue 2, p441-445, 5p
Abstrakt:	To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin's lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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