Lipoxin A Suppresses Lipopolysaccharide-Induced Hela Cell Proliferation and Migration via NF-κB Pathway.

Autor: Hao, Hua, Xu, Fen, Hao, Jian, He, Yuan-Qiao, Zhou, Xiao-Yan, Dai, Hua, Wu, Li-Qing, Liu, Fan-Rong
Předmět:
Zdroj: Inflammation; Feb2015, Vol. 38 Issue 1, p400-408, 9p
Abstrakt: Uterine cervical carcinoma (UCC) is one of the most common malignant tumors in females, and UCC has a close relationship with chronic cervicitis. As the endogenous 'braking signal,' lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxin A (LXA) on the proliferation, apoptosis, and migration in lipopolysaccharide (LPS)-stimulated Hela cells. We demonstrated that LXA could significantly suppress p53, cyclin D1 expression, and migration of LPS-stimulated Hela cells via nuclear factor-κB (NF-κB) pathway, and these effects could be blocked by Boc-2, the specific inhibitor of FPR2/ALX (the receptor of LXA). We presented evidence for a novel role of LXA on the proliferation and migration in LPS-stimulated Hela cells, and FPR2/ALX was involved in the procedures. These results showed that LXA could be a possible candidate for UCC therapy, and blocking the activation of NF-κB would be an effective drug target. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index