White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats.
Autor: | Yong-Zhuo Liang, Hai-Ming Chen, Zu-Qing Su, Shao-Zhen Hou, Xiao-Ying Chen, Yi-Feng Zheng, Yu-Cui Li, Ji Lin, Janis Ya-Xian Zhan, Zi-Ren Su, Lu-Di Fu |
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Předmět: |
ALTERNATIVE medicine
ANIMAL experimentation BIOAVAILABILITY BIOPHYSICS COMPARATIVE studies DRUG synergism DRUG-food interactions HIGH performance liquid chromatography INTRAVENOUS injections INTESTINAL absorption RESEARCH methodology MEDICINAL plants ORAL drug administration PROBABILITY theory RATS RESEARCH funding SPICES STATISTICAL hypothesis testing T-test (Statistics) PLANT extracts ISOFLAVONES DESCRIPTIVE statistics |
Zdroj: | Evidence-based Complementary & Alternative Medicine (eCAM); 2014, Vol. 2014, p1-8, 8p, 2 Charts, 6 Graphs |
Abstrakt: | This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400mg/kg) or intravenous injection (40mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20mg/kg) increased the C |
Databáze: | Complementary Index |
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