White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats.

Autor:	Yong-Zhuo Liang, Hai-Ming Chen, Zu-Qing Su, Shao-Zhen Hou, Xiao-Ying Chen, Yi-Feng Zheng, Yu-Cui Li, Ji Lin, Janis Ya-Xian Zhan, Zi-Ren Su, Lu-Di Fu
Předmět:	ALTERNATIVE medicine ANIMAL experimentation BIOAVAILABILITY BIOPHYSICS COMPARATIVE studies DRUG synergism DRUG-food interactions HIGH performance liquid chromatography INTRAVENOUS injections INTESTINAL absorption RESEARCH methodology MEDICINAL plants ORAL drug administration PROBABILITY theory RATS RESEARCH funding SPICES STATISTICAL hypothesis testing T-test (Statistics) PLANT extracts ISOFLAVONES DESCRIPTIVE statistics
Zdroj:	Evidence-based Complementary & Alternative Medicine (eCAM); 2014, Vol. 2014, p1-8, 8p, 2 Charts, 6 Graphs
Abstrakt:	This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400mg/kg) or intravenous injection (40mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20mg/kg) increased the Cmax of puerarin by 1.30-fold or 1.64-fold and the AUC0-∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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