A Homogeneity Study Using NIR Spectroscopy: Tracking Magnesium Stearate in Bohle Bin-Blender.

Autor:	Duong, Nhat-Hang, Arratia, Paulo, Muzzio, Fernando, Lange, Andrew, Timmermans, Joep, Reynolds, Scott
Předmět:	NEAR infrared spectroscopy POWDERS MIXING LUBRICATION & lubricants
Zdroj:	Drug Development & Industrial Pharmacy; Jul2003, Vol. 29 Issue 6, p679-687, 9p, 1 Chart
Abstrakt:	A method was developed for studying mixing of cohesive pharmaceutical mixtures. A combination of accurate sampling and NIR spectroscopic analysis was developed as a suitable method to determine homogenization of magnesium stearate as a function of blending variables. A typical pharmaceutical blend containing a ratio 35:64:1 lactose, avicel, and magnesium stearate was used as a model system. The method accounted for variability of the concentration of magnesium stearate as well as variability of the excipients. Levels of magnesium stearate as low as 0.05% could be resolved by the method, and showed a predicting confidence interval above 98%. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.