Synthesis of 5-Carbonyl-1,3-dihydro- 1,3-dioxo-2H-isoindole-2-propanoic Acid Integrin Antagonists.

Autor: Deng, Yong, Shen, Yi, Zhong, Yu-Guo
Předmět:
Zdroj: Synthetic Communications; 2003, Vol. 33 Issue 12, p2109-2117, 9p
Abstrakt: The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa–e), which then hydrogenolyzed by 5% palladium-on-carbon to give target compounds (IVa–e). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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